On this Sunday, April 20, 2025, top MLB DFS picks include standout pitchers and valuable hitters across both DraftKings and FanDuel. Jesus Luzardo, facing the Miami Marlins, shows tremendous strikeout potential with a solid 2.31 ERA and has struck out 29 batters in 23.2 innings. Meanwhile, Tarik Skubal is on a hot streak, with 13 consecutive shutout innings against the Kansas City Royals, making him a prime target. Hitting-wise, the Boston Red Sox's Rafael Devers is now finding his rhythm, while Gunnar Henderson of the Baltimore Orioles is also emerging as a sleeper pick following a recent strong showing.

With matchups at Boston's Fenway Park and Coors Field, where high-scoring games are anticipated, there's potential for explosive performances. Stacking players from these games provides an edge for DFS players. The Boston Red Sox's matchup against Sean Burke and the Philadelphia Phillies against Connor Gillispie are particularly enticing. Look for a combination of Devers, Abreu, and Turner to capitalize on these favorable conditions.

As always, stay updated on injury news and lineup changes, which are critical for optimizing your DFS lineups today.