The Chicago White Sox are facing significant challenges as they enter the 2025 season, placing infielders Josh Rojas and Bryan Ramos, along with outfielder Mike Tauchman, on the 10-day injured list. Rojas is sidelined with a right toe fracture while Ramos deals with a right elbow strain, and Tauchman has a right hamstring strain. To bolster their roster, the team activated right-hander Mike Clevinger, outfielder Travis Jankowski, and infielder Nick Maton, all of whom signed minor league deals in the offseason.

Additionally, left-hander Tyler Gilbert has been placed on the 15-day injured list due to left knee bursitis, and right-hander Drew Thorpe will miss the entire season after undergoing Tommy John surgery. Despite his recent injury, Andrew Benintendi is in the starting lineup as the designated hitter and is expected to return to outfield play later in the opening series.