The Chicago White Sox faced a tough start to their season-long 10-game road trip, suffering a 10-3 loss to the Boston Red Sox. Pitcher Martín Pérez struggled early, allowing a three-run homer from Trevor Story in the first inning before exiting the game with forearm discomfort after just three innings. Pérez's performance was further marred by fatigue and difficulty with command, leading to four runs on five hits. This loss marked the White Sox's fifth straight defeat and continued a troubling trend of poor performance, with the team now slipping to 4-15 overall.

Despite the setback for Pérez, who initially had a promising start to the season with a 3.15 ERA, manager Will Venable expressed confidence in his leadership abilities and the importance of his experience within the team. The White Sox bullpen, already stretched thin, was forced to pitch the remaining six innings. The Red Sox showcased their power with multiple homers, including another three-run blast from Story in the seventh inning, sealing the game against a beleaguered White Sox squad that has struggled immensely on the road.