As the 2025 MLB season progresses, identifying two-start pitchers can significantly impact your fantasy lineup. Several pitchers are poised for strong performances in the week of April 21. Kris Bubic stands out with a 1.88 ERA and favorable matchups against the Rockies and Astros. Hunter Brown, boasting a 1.50 ERA, is also an excellent option with starts against the Rays and Royals. Jack Flaherty offers two enticing home matchups against the Padres and Orioles, while Jose Soriano's recent form suggests he might add value against the Pirates and Twins.

Bailey Ober is projected to turn around his season against the White Sox and Angels, and Bryce Miller looks reliable with solid starts against the Red Sox and Marlins. Conversely, pitchers such as Osvaldo Bido and Dean Kremer face challenges, while high-risk options like Sean Newcomb and Jonathan Cannon may not yield the desired results. Targeting the right two-start pitchers can be crucial in enhancing your fantasy standings.