LSU continues its tradition of producing top-tier baseball talent, with eight former players making the MLB opening day rosters. Paul Skenes and Dylan Crews, fresh from a national championship win in 2023, made their debuts. Skenes, now with the Pittsburgh Pirates, delivered an impressive rookie season, boasting a 1.96 ERA with 170 strikeouts, earning him the NL Rookie of the Year award. Meanwhile, Crews, playing for the Washington Nationals, is set to make an impact in the outfield with his speed and power.

Among the notable alumni are Alex Bregman, now with the Boston Red Sox, who has made a name following his time with the Houston Astros. Kevin Gausman and Aaron Nola, both former standout pitchers at LSU, have also transitioned well into their MLB careers. The Yankees' DJ LeMahieu remains a reliable bat in the lineup, while Josh Smith and Jake Fraley are making their mark with the Rangers and Reds, respectively. As LSU’s baseball program thrives, these players will continue to represent their roots on the big stage.

The 2025 MLB season has officially kicked off, featuring 28 of the 30 MLB teams on Opening Day. Highlighting the event are the Los Angeles Dodgers and New York Yankees, last year's World Series participants. Notably, Lars Nootbaar stands out as the only USC alum on an active MLB roster, having played 109 games for the St. Louis Cardinals in 2024. Garrett Stubbs, previously the No. 2 catcher for the Philadelphia Phillies, has been optioned to Triple-A. Other former Trojans like Kyle Hurt and Tyler Gilbert are sidelined with injuries, while Blake Sabol starts the season in Triple-A with the Boston Red Sox.

The roster also features notable coaches from USC, including Yankees manager Aaron Boone and Dodgers pitching coach Mark Prior, emphasizing USC's lasting impact in Major League Baseball.