Major League Baseball reported only two positive tests for performance-enhancing drugs in the year concluding with the World Series, a significant drop from previous years. The total number of tests conducted was 11,609, which includes both urine and blood samples.

Among the positive tests, Cincinnati Reds infielder Noelvi Marté received an 80-game suspension for boldenone, while Toronto Blue Jays infielder Orelvis Martínez was suspended for clomiphene. The report also noted a consistent low in exemptions for attention deficit hyperactivity disorder.