The opening game of the 2025 NBA playoffs features a rematch between the Indiana Pacers and the Milwaukee Bucks, with the Pacers holding home court advantage. Indiana, the 4-seed, looks to replicate their success from last season’s playoffs where they defeated the Bucks, though Giannis Antetokounmpo was sidelined due to injury. This season, the Bucks won three out of four regular-season matchups against the Pacers, showcasing their potential despite being the lower seed. The injury concerns for Milwaukee include Damian Lillard, who is out for Game 1 due to a blood clot.

Pundits suggest that the Pacers, with their strong home record, are positioned favorably, especially as they boast a 7-1 record over their last eight games. However, the Bucks have been on an eight-game winning streak, with Antetokounmpo performing exceptionally as a point forward, averaging a staggering 30.8 points, 13.4 rebounds, and 12 assists in his recent games. Betting lines favor the Pacers by 6 points, with an over/under set at 225 points. As both teams enter this highly-anticipated matchup, the stakes and excitement are palpable, making it a must-watch for fans and bettors alike.