Tua Tagovailoa is not carrying an injury designation for Week 16, indicating he is healthy and ready to play. This positions him as a reliable option for fantasy managers during the critical playoff stage.

Jaylen Waddle is doubtful to play against the San Francisco 49ers due to a knee injury that forced him to miss all three practices this week. His absence could significantly affect the Dolphins' offensive strategy as they fight for playoff positioning.

Tyreek Hill is questionable for the upcoming game due to a wrist/personal issue. After a limited practice week, he is expected to be active, but fantasy managers should verify his status before the game.

The Miami Dolphins defense is ranked 21st in Week 16, indicating a challenging matchup ahead. Despite some decent performances, the unit has struggled to consistently provide value, making them a less favorable option for fantasy managers this week.

De'Von Achane is poised for a significant performance this weekend, having averaged 11 rushing attempts and at least seven targets per game over his last three outings. He has consistently tallied over 70 all-purpose yards in each game, showcasing elite usage. This week, he faces the San Francisco 49ers, who have allowed the tenth-most PPR points to opposing running backs, presenting Achane with a strong opportunity to excel.