The St. Louis Cardinals face off against the Chicago Cubs in the decisive game of their weekend series, having split the first two games. The Cardinals took Saturday's contest 8-6, while the Cubs won the opener convincingly 11-3. Erick Fedde, with a 3-8 record and a 4.56 ERA, will start for St. Louis, while the Cubs counter with the impressive Matthew Boyd, who holds an 8-3 record and a 2.65 ERA. The betting odds give the Cubs the edge at -207, with a total runs over/under set at 7.5.

Recent performance trends favor the Cubs, who have won four of their last five games and six of the last ten against the Cardinals. The predictive model suggests the Cubs have a nearly 70% chance of winning, projecting them to win by an average score of 5.1 to 3.8, with St. Louis likely to cover the run line at +1.5.

The Cleveland Guardians (40-43) are set to face the Chicago Cubs (50-35) at Wrigley Field this evening, with Tanner Bibee taking the mound for the Guardians against Shota Imanaga for the Cubs. Last night, the Cubs won the first game of the series 5-2, with Carson Kelly shining by going 2-for-2 and driving in three runs, while Matthew Boyd pitched well, allowing only two runs in seven innings for his eighth win of the season.

This matchup is significant as the Cubs aim to capitalize on their recent home success against teams with losing records, having won four of their last five such games. The Guardians, meanwhile, have struggled against the Cubs in recent encounters, failing to cover the Run Line in eight of their last ten games. Bettors should consider the latest odds, which currently favor the Cubs at -159 on the moneyline, while the Guardians are listed at +134. The total runs are set at 9.0, hinting at a potential low-scoring affair given the Guardians' recent trend of underwhelming offensive output.

Today's MLB DFS slate features nine games, kicking off at 6:40 p.m. ET, bringing together compelling matchups including the Cubs vs. Phillies and significant interleague contests. A wealth of pitching talent will grace the mound, notably Chris Sale, who has shown tremendous form lately with a 2.93 ERA and 72 strikeouts in his last 54.2 innings. Joining him are Matthew Boyd, who continues to excel for the Cubs, and rookie Eury Perez, making his highly anticipated return after Tommy John surgery against the struggling Pirates.

As for hitters, Jose Ramirez stands out, especially when facing left-handed pitchers like Wade Miley, demonstrating a .417 average against them this season. Yandy Diaz's powerful history against Boston's Brayan Bello cannot be overlooked, and both Jarren Duran and Shohei Ohtani are in line for potential big performances against respective right-handers.

The Chicago Cubs take on the Washington Nationals tonight, following a strong 8-3 victory in the first game of the series, marking their third consecutive win and seven out of their last eight games.

Matthew Boyd is set to pitch for the Cubs, boasting a solid record of 5-2 with a 3.08 ERA, while MacKenzie Gore takes the mound for the Nationals with a 2-5 record and a 3.16 ERA. The Cubs have thrived with Boyd on the mound, winning five of his last six starts. The Nationals, however, have struggled, winning only five out of 12 starts with Gore this season.

Recent trends suggest the Cubs are performing well on the road, winning five of their last six games away from home. Despite this, the over has been a common outcome in Cubs games, hitting at a 34-21-5 rate this season. Betting odds favor the Cubs at -136 on the moneyline, while the Nationals sit at +115. The total runs for the game is set at 8.0, with betting recommendations leaning towards the over and a spread play on the Nationals at +1.5.

On May 23, 2025, the Chicago Cubs (30-20) face off against the Cincinnati Reds (25-26) at Great American Ball Park. Cubs' Matthew Boyd, boasting a 2.98 ERA, aims to continue the team's winning streak, having won five of their last six games. Meanwhile, Hunter Greene, with an impressive 2.37 ERA, takes the mound for the Reds, who are looking to break a two-game losing streak after winning five straight.

The matchup comes with tight odds. The Cubs are slight favorites at -115 on the moneyline, while the Reds are at -104. The total runs are set at 8.0, indicating a potentially high-scoring game. Boyd’s recent performance includes a solid outing where he allowed three earned runs across six innings. Greene's last start saw him shut out opponents for three innings. Betting trends suggest the Cubs have excelled against teams with losing records, while the Under often hits when Greene is pitching.