As we gear up for the MLB DFS action on April 16, 2025, savvy players will want to explore the recommended lineup picks across both FanDuel and DraftKings. The slate includes 10 games starting at 6:35 PM ET, with a promising mix of elite pitchers and value options.

For pitching, Brandon Pfaadt of the Arizona Diamondbacks stands out with his strong strikeout capabilities, particularly against the Miami Marlins, who struggle against right-handed pitching. Meanwhile, Aaron Nola from the Philadelphia Phillies offers both consistency and a solid matchup against the San Francisco Giants.

Kris Bubic from the Kansas City Royals is a high-risk, high-reward play against a powerful Yankees lineup. Offensively, Rafael Devers is poised to capitalize against the vulnerable Zack Littell, while Pavin Smith and Jose Ramirez represent intriguing infield options. Outfielders such as Brent Rooker and Corbin Carroll also provide considerable upside. The Dodgers, Diamondbacks, and Royals are highlighted as the top stacking options against favorable pitching matchups.