As the 2025 MLB season progresses, identifying two-start pitchers can significantly impact your fantasy lineup. Several pitchers are poised for strong performances in the week of April 21. Kris Bubic stands out with a 1.88 ERA and favorable matchups against the Rockies and Astros. Hunter Brown, boasting a 1.50 ERA, is also an excellent option with starts against the Rays and Royals. Jack Flaherty offers two enticing home matchups against the Padres and Orioles, while Jose Soriano's recent form suggests he might add value against the Pirates and Twins.

Bailey Ober is projected to turn around his season against the White Sox and Angels, and Bryce Miller looks reliable with solid starts against the Red Sox and Marlins. Conversely, pitchers such as Osvaldo Bido and Dean Kremer face challenges, while high-risk options like Sean Newcomb and Jonathan Cannon may not yield the desired results. Targeting the right two-start pitchers can be crucial in enhancing your fantasy standings.

Today's MLB DFS slate offers a mix of top-tier pitchers and undervalued players to target. Brandon Pfaadt stands out against a struggling Miami lineup, boasting a solid strikeout rate that makes him a must-start in cash games and GPPs. Aaron Nola's matchup with the San Francisco Giants presents a high floor option for consistency, while Kris Bubic's breakout potential against the Yankees adds significant upside for tournament play. Value picks like Rafael Devers and Pavin Smith promise a strong offensive output, especially against pitchers with exploitable splits.

In the outfield, Brent Rooker and Corbin Carroll are poised for big games against favorable matchups. Stacking the Los Angeles Dodgers against German Marquez and the Arizona Diamondbacks against Max Meyer could yield high returns. Weather conditions seem favorable for both games, making it a perfect night for DFS enthusiasts. Stay updated on injury news and starting lineups to maximize your chances for success in today's contests.

As we gear up for the MLB DFS action on April 16, 2025, savvy players will want to explore the recommended lineup picks across both FanDuel and DraftKings. The slate includes 10 games starting at 6:35 PM ET, with a promising mix of elite pitchers and value options.

For pitching, Brandon Pfaadt of the Arizona Diamondbacks stands out with his strong strikeout capabilities, particularly against the Miami Marlins, who struggle against right-handed pitching. Meanwhile, Aaron Nola from the Philadelphia Phillies offers both consistency and a solid matchup against the San Francisco Giants.

Kris Bubic from the Kansas City Royals is a high-risk, high-reward play against a powerful Yankees lineup. Offensively, Rafael Devers is poised to capitalize against the vulnerable Zack Littell, while Pavin Smith and Jose Ramirez represent intriguing infield options. Outfielders such as Brent Rooker and Corbin Carroll also provide considerable upside. The Dodgers, Diamondbacks, and Royals are highlighted as the top stacking options against favorable pitching matchups.

The Kansas City Royals are facing off against the New York Yankees in a critical matchup at Yankee Stadium. Kris Bubic, holding a stellar 0.96 ERA, will pitch for the Royals, aiming to stop their recent slide, having lost four of their last five games. Meanwhile, the Yankees, buoyed by Jasson Dominguez's recent performance, which included a bases-clearing double leading to a 4-2 victory in the last game, are looking to extend their winning streak.

With the Yankees favored at -167, the current odds reflect their recent form, winning three of their last four games, while the Royals seek to avoid a series sweep. Expect a competitive contest with the total set at 8.0 runs. The Royals need to capitalize on Bubic's strong start to turn their season around.