Kyle Manzardo delivered a standout performance for the Cleveland Guardians, going 3-for-4 with a home run and four RBIs, leading the team to a 7-4 victory over the Kansas City Royals in 10 innings on Opening Day. The Guardians managed to rebound from an early 3-0 deficit, with Manzardo's critical two-run homer in the sixth and a two-run double in the 10th. Steven Kwan provided the game-winning hit with a tie-breaking double, while Paul Sewald secured the save.

The Royals' Vinnie Pasquantino hit a three-run homer but ultimately fell short, leaving them looking for answers as they start the season 0-3 under manager Matt Quatraro. Emmanuel Clase, who had a stellar previous season, faced struggles in the ninth, allowing the Royals to tie the game before the Guardians pulled away in extras.