In a competitive clash, the Cleveland Guardians fell 5-2 to the San Diego Padres, who improved their franchise-record start to a 7-0. Key moments included homers from Jackson Merrill and Luis Arraez, with Arraez's being his first of the season. The Guardians struggled against Dylan Cease, who allowed just one run over 6 1/3 innings. Cleveland's Ben Lively took the loss after yielding four runs in 4 1/3 innings, hampered by a crucial third inning where he lost control after two quick outs.

The Padres took an early lead with a unique double steal, showcasing their aggressive base-running. Cleveland’s late-game efforts included a groundout from Lane Thomas and a sacrifice fly from Kyle Manzardo, but ultimately, they couldn’t capitalize on their chances to tie the game.