The San Diego Padres suffered their first loss of the 2025 season, falling 3-1 to the Chicago Cubs at Wrigley Field. The defeat ended their perfect start of 7-0. Meanwhile, the Los Angeles Dodgers remained the only undefeated team in Major League Baseball with an 8-0 record. Cubs pitcher Shota Imanaga shone with 7.1 innings of work, allowing just one run and striking out four. The Cubs took the lead in the fifth inning with two runs following a series of walks from Padres starter Randy Vásquez, who struggled with control.

The Padres managed to tie the game in the fourth inning with Martín Maldonado's home run, but the Cubs capitalized on Vásquez's erratic pitching to secure the win. The Cubs' bullpen, featuring Porter Hodge and Ryan Pressly, closed out the game strong, with Pressly earning his third save despite a brief scare in the ninth.