San Francisco’s Week 6 setback vs. Tampa Bay exposed injury-depleted depth and a string of costly mistakes. Fred Warner’s ankle injury crippled the defense’s leadership, and Nick Bosa’s season-ending ACL injury left the pass rush thin. The 49ers’ lack of interceptions extended to 13 straight games, while their only sack came from rookie Mykel Williams. Offensively, Mac Jones threw for 347 yards with two picks and six sacks, yet Kendrick Bourne delivered another big game with 142 yards on five catches. Eddy Pineiro was perfect on four field goals, and SF’s rushing attack stagnated at 67 yards. A late fourth-quarter penalty and two turnovers sealed the loss, but San Francisco still leads the NFC West at 4-2 as other contenders pace the division.

Penned as a game of margin for error, the result highlights how injuries and discipline swing outcomes in close games. SF must lean on Bourne’s versatility and Pineiro’s reliable leg while hoping health returns to the defensive leaders. Until Bosa and Warner return, the meticulous, mistake-free football that carried SF earlier in the year is harder to maintain.