The Philadelphia 76ers are facing a challenging matchup against the undefeated Cleveland Cavaliers after a tough game against the New York Knicks. With key players Joel Embiid, Paul George, Tyrese Maxey, and Andre Drummond all sidelined, coach Nick Nurse is forced to implement a new starting lineup.

Rookie Jared McCain will make his first NBA start, coming off impressive performances in previous games. The Cavaliers, led by Donovan Mitchell, are currently the last unbeaten team in the league, posing a significant challenge for the depleted Sixers.