The Titans head into Week 2 vs. the Rams with a noticeable injury cloud on the depth chart. Four players were sidelined after the first practice: Quandre Diggs (hand), JC Latham (hip), Kalel Mullings (high ankle), and T'Vondre Sweat (ankle).

Diggs logged 31 defensive snaps in Week 1, while Latham started on the line and Mullings appeared in preseason and Week 1. Sweat has been limited after a tonsillectomy and an ankle issue. Oli Udoh could slot in for Latham if the hip lingers, testing the Titans’ offensive line and backfield depth.

Linebacker Arden Key, cornerback L'Jarius Sneed, and rookie Kevin Winston Jr. were limited in practice, signaling that Tennessee’s depth players may be leaned on if injuries persist. Health remains a priority as the Titans prepare for the Rams and fantasy managers watch for any pivots in personnel.

Stay tuned for updated practice notes, especially around Diggs, Mullings, and Sweat, since any downgrade could amplify opportunity for backups in a pivotal Week 2 clash that could shape early-season fantasy projections.

Tennessee’s defense leans on interior disruption, with Simmons anchoring the line alongside Sweat and Joseph-Day, producing elite run-stop and solid pass-rush presence. Offensively, Ridley stands as the clear top target, while Ward’s college ceiling adds speculative upside for a reforming attack. Spears could emerge as a key fantasy piece as a versatile back, though questions linger at linebackers, where youth and turnover loom. A rookie safety adds intrigue in the Titans’ secondary.

The preview highlights how interior strength could power favorable game scripts, letting Ridley and Spears flourish in better-made opportunities, but the lack of proven linebacker play could constrain the defense’s overall ceiling. Expect Titans’ fantasy pathways to lean on Ridley’s volume, Spears’ multi-role usage, and potential breakout plays from defensively disruptive alignments.