The Astros lost a series to the Twins after a walk-off home run by Christian Vázquez. The winning streak ended, with Josh Hader struggling as closer. Minnesota catcher Vázquez drove the final blow, crushing a full-count slider for the win. The Astros' offense struggled in clutch situations, leaving runners stranded and squandering opportunities. Hader allowed multiple home runs, continuing a tough stretch.

Pressly pitched well to give the Astros a chance, but the offense couldn't capitalize. Arrighetti battled through some defensive lapses to keep the game close. The Astros had a tough time against Twins' pitcher Woods Richardson. It was a hometown matchup for Richardson, who stifled the Astros' right-handed hitters. Carlos Correa exited the game early after being hit by a pitch, adding to the Astros' injury woes.