The injuries to key pitchers Shane McClanahan, Shohei Ohtani, and Spencer Arrighetti raise concerns for fantasy managers as they navigate the start of the 2025 MLB season. McClanahan, who recently experienced an inflamed nerve in his left triceps, remains on the 15-day injured list without a defined return date, but he’s optimistic about recovery. Meanwhile, Ohtani continues to excel as a designated hitter following his Tommy John surgery, but there’s no timetable for his return to pitching. Arrighetti's promising start was cut short by a broken thumb, though he is expected to avoid surgery and might return around early June. Managers should monitor these players closely as they possess significant fantasy upside.