The San Francisco 49ers have faced challenges this season with a 2-2 record, largely due to injuries affecting key players like Christian McCaffrey, Deebo Samuel, and George Kittle. Despite these setbacks, there is optimism for improvement as players return. However, the defense remains a concern, particularly with Fred Warner's injury impacting performance.

On the other hand, the Arizona Cardinals, currently at 1-3, have struggled with consistency, particularly on offense, despite having talented players like Kyler Murray and Marvin Harrison Jr. Both teams are preparing for their upcoming matchup, with the 49ers favored to win.