JuJu Smith-Schuster is set to return from a hamstring injury but should be left on fantasy benches this week. Despite being back in practice as a full participant, he has only one notable game this season, catching seven passes for 130 yards. With the addition of DeAndre Hopkins, Smith-Schuster faces significant competition for targets, diminishing his value as a fantasy starter.

Patrick Mahomes leads the Kansas City Chiefs into a crucial matchup against the Buffalo Bills, showcasing his role in maintaining the team's perfect 9-0 record. His performance is central to the Chiefs' success and their ability to attract significant viewership, highlighting the impact of star players in the NFL's competitive landscape.

The undefeated Chiefs, currently leading with a 9-0 record, will face the Bills, who are looking to regroup before their bye week. This matchup presents a significant challenge for Buffalo as they contend with injuries to key players, including Kincaid and Coleman, against a formidable opponent.

JuJu Smith-Schuster was a full participant in Friday's practice, indicating he is ready to play without any injury designation for the upcoming game. This development is positive for the Chiefs as they look to maintain their offensive momentum.

Isiah Pacheco is listed as out for the upcoming game due to an ankle injury, impacting the Kansas City Chiefs' backfield depth and fantasy football lineups.