The Buffalo Bills are set to debut a revamped offense in their season opener against the Arizona Cardinals, featuring new receivers Curtis Samuel, Kahlil Shakir, and Keon Coleman in place of Stephon Diggs and Gabe Davis.

Despite concerns about their defense following the loss of key players, including Matt Milano and Pro Bowl safeties Jordan Poyer and Micah Hyde, Josh Allen remains the pivotal presence at quarterback.

On the other hand, the Cardinals, led by a healthy Kyler Murray and bolstered by rookie wide receiver Marvin Harrison, Jr., are hopeful for a successful season, though their defense appears to need improvement.