The Arizona Cardinals (7-9) will face off against the San Francisco 49ers (6-10) in a Week 18 matchup that holds little playoff significance but could impact draft positioning. The 49ers, once expected to be top contenders in the NFC, have suffered numerous injuries, including to quarterback Brock Purdy, who will miss the season finale. In his place, veteran Josh Dobbs will start, marking his first appearance of the season.

Despite a tumultuous season, Cardinals quarterback Kyler Murray has managed to start all 16 games, leading the team through a rollercoaster campaign. The Cardinals are looking to improve their standing as they enter the final week, while several players on both teams are eyeing contract incentives based on their performances.