The Buffalo Bills, contrary to expectations of a rebuild in the 2024 NFL season, are positioned for a strong Super Bowl run, currently ranking second in the AFC. Their next challenge is against the Indianapolis Colts, a team fighting for playoff survival.

Key matchups to watch include Bills' defensive tackles against rookie center Tanor Bortolini, slot receiver Khalil Shakir facing top corner Kenny Moore II, and the Bills' offensive line contending with Colts' defensive stars DeForest Buckner and Grover Stewart.