The Buffalo Bills are facing a significant setback as tight end Dalton Kincaid will miss the upcoming game against the San Francisco 49ers due to a knee injury. This marks Kincaid's second consecutive absence, following his injury sustained in Week 10 against the Indianapolis Colts.

Kincaid has been a crucial part of the Bills' offense, ranking as Josh Allen's second-most-targeted player this season. His absence adds to the challenges faced by the Bills, who are already dealing with injuries to key wide receivers.