San Francisco 49ers running back Isaac Guerendo has showcased impressive explosiveness this season, but his role may diminish with the anticipated return of Christian McCaffrey from injury. Head coach Kyle Shanahan's reliability regarding player injuries has been questionable, leading to uncertainty for fantasy managers.

Meanwhile, other running backs like Tyler Allgeier and Travis Etienne Jr. are also facing challenges, with Allgeier serving primarily as a handcuff and Etienne struggling against a tough defense. Tight end Jonnu Smith and quarterback Justin Herbert have shown promise in their respective roles, with Smith maintaining consistent targets and Herbert improving his fantasy standing.