The Philadelphia Eagles are heavy favorites against the Carolina Panthers, with a 12-point spread, largely due to their top-ranked rushing attack facing off against the Panthers' struggling run defense.
Star running back Saquon Barkley is expected to excel, leading the league with 1,499 rushing yards. Panthers edge rusher DJ Wonnum acknowledges the challenge of stopping Barkley, emphasizing teamwork and physicality.
The Panthers face a tough task, especially without defensive tackle Derrick Brown, who is on injured reserve. This matchup could be a turning point for Carolina's defense.
