The injury report for NFL running backs heading into Week 18 reveals significant updates that could impact fantasy football lineups. Saquon Barkley is set to sit out as the Philadelphia Eagles prioritize his health for the playoffs, while Bucky Irving has been cleared to play following shoulder and shin issues, positioning him as a strong RB1 option against the Saints.

Josh Jacobs is also expected to play, albeit with limited workload expectations, which may affect his fantasy value. Kyren Williams will not participate as the Rams rest him for playoff contention, leaving Blake Corum to lead the backfield.

Other notable updates include Alvin Kamara being doubtful due to a groin injury, while Aaron Jones is cleared to play and will likely have a substantial role. Tony Pollard's status is questionable due to an ankle injury, and Jaylen Warren is cleared to play and could see significant action against the Bengals.