As the San Francisco 49ers prepare for the 2025 NFL Draft, their offseason has seen significant player movement, with 20 roster changes including trades, releases, and free agency departures. The 49ers lost key players who contributed to a combined 209 games with 115 starts last season, primarily due to injuries. In response, they have signed nine new players who collectively played 140 games last year, seeking to fill the gaps left by departed veterans.

Key players like linebacker Dre Greenlaw and defensive tackle Javon Hargrave are among those now elsewhere, while the team has also re-signed several contributing players to retain some continuity. With the new acquisitions and draft strategies on the horizon, the 49ers aim to remain competitive in the highly contested NFC West.