The Detroit Lions faced multiple injury concerns during their game against the Indianapolis Colts, particularly in the third quarter. Kalif Raymond suffered a left foot injury after a punt return, while left tackle Taylor Decker injured his right ankle and knee but managed to return to the game.

Running back David Montgomery also sustained a shoulder injury but rejoined the sidelines later. Cornerback Carlton Davis left the game with a knee injury, leaving the Lions' secondary compromised. Coach Dan Campbell expressed uncertainty about the players' availability for the upcoming Thanksgiving game against the Chicago Bears.