The Houston Texans face uncertainty heading into Week 5 as their starting running back, Joe Mixon, missed practice for the second consecutive day due to an ankle injury. His availability for the upcoming game against the Buffalo Bills remains in doubt.

Backup Dameon Pierce is also sidelined, which could lead to Cam Akers taking the lead in the backfield. Despite some injury concerns, left tackle Laremy Tunsil returned to practice, providing hope for quarterback C.J. Stroud's protection against a formidable Bills pass rush.