In an intense matchup, the Houston Texans defeated the Indianapolis Colts 29-27, with Stefon Diggs and Joe Mixon playing pivotal roles. Diggs secured two touchdown receptions while Mixon dominated the ground game with 159 rushing yards and a touchdown.
The game was marked by the Colts extending their winless streak on opening day to 11 games despite impressive TD passes from Anthony Richardson. C.J. Stroud also showcased his talent, leading the Texans to victory.