The Houston Texans are set to face the Buffalo Bills in a crucial AFC matchup, with CBS broadcasting the game. The Texans will experience yet another change in their offensive line, as starting right tackle Tytus Howard is sidelined, leading to rookie Blake Fisher's debut at the position.

Steven Sims is inactive after a fumble last week, while options for returner include Tank Dell and Robert Woods. Linebacker Azeez Al-Shaair will play despite recent illness, and edge rusher Dylan Horton makes his return after battling cancer.