The Indianapolis Colts and Pittsburgh Steelers are set to clash at Lucas Oil Stadium but are both facing significant injury challenges. The Colts are missing key defenders, including Kenny Moore II and Kwity Paye, while center Ryan Kelly is inactive. The Steelers have also ruled out several players, including Alex Highsmith and Jaylen Warren, with Russell Wilson listed as questionable.

With Kelly out, rookie Tanor Bortolini will make his NFL debut. The Colts have also elevated Adam Gotsis and David Long Jr. from the practice squad. The absence of Highsmith will test the Steelers' defense, though Nick Herbig has shown promise as his replacement.