The Indianapolis Colts are poised to make a critical push in the 2025 NFL season after a dismal playoff streak. General manager Chris Ballard and head coach Shane Steichen remain at the helm, with quarterback Anthony Richardson receiving another opportunity to prove himself as a starter. However, the upcoming schedule is daunting, featuring tough matchups against some of the league's best.

Beginning with a challenging away game against the Kansas City Chiefs, who have maintained a dominant home record under MVP Patrick Mahomes, the Colts face a steep uphill battle. Their subsequent game against the Los Angeles Rams, a team that has historically bested them, and a home matchup with the talented San Francisco 49ers present further challenges.