The Indianapolis Colts are preparing for their matchup against the Buffalo Bills with a mostly clean injury report, featuring notable players like linebacker Zaire Franklin and offensive tackles Bernhard Raimann and Braden Smith ready to play. However, star receiver Michael Pittman Jr. will miss the game due to a lingering back injury, impacting the Colts' offensive strategy.

With Pittman sidelined, pass-catchers Josh Downs, Alec Pierce, and AD Mitchell will need to step up to support quarterback Joe Flacco. Running back Jonathan Taylor is also expected to improve after a lackluster performance against the Minnesota Vikings. On the Bills' side, rookie receiver Keon Coleman is out, leading to increased targets for Khalil Shakir and Amari Cooper. This game poses a significant challenge for the Colts as they aim to overcome their offensive struggles and contain quarterback Josh Allen.