The Indianapolis Colts are preparing for a crucial Week 16 game against the Tennessee Titans, with several key players listed as questionable. Tight end Mo Alie-Cox, wide receiver Ashton Dulin, kicker Matt Gay, cornerback JuJu Brents, linebacker Jaylon Carlies, and center Ryan Kelly are all dealing with injuries. Brents may play but likely in a limited role, while Kelly's potential return would mark his first game action since November.

Notably, the Colts will miss wide receiver Alec Pierce and linebacker E.J. Speed due to their respective injuries. This opens opportunities for players like AD Mitchell to step up. With the Titans being a seemingly favorable matchup, the Colts must avoid complacency and ensure their game plan is executed effectively to secure a win at Lucas Oil Stadium.