The Indianapolis Colts face a pivotal matchup against the Buffalo Bills, with both teams having contrasting seasons so far. The Colts, sitting at 4-5, must find ways to disrupt the impressive play of Bills quarterback Josh Allen, who has been exceptionally efficient this year.

Key strategies for the Colts include applying pressure on Allen, reviving Jonathan Taylor's performance, and containing key receivers like Khalil Shakir and Dalton Kincaid. Additionally, Joe Flacco's performance will be crucial as he steps in for the benched Anthony Richardson.