In NFL Week 2, the Buffalo Bills dominated the Miami Dolphins 31-10, with James Cook scoring three touchdowns and Tua Tagovailoa exiting due to a concussion. The Minnesota Vikings edged the San Francisco 49ers 23-17, buoyed by Sam Darnold's two touchdown passes.

The New York Jets overcame the Tennessee Titans 24-17, while the Los Angeles Chargers defeated the Carolina Panthers 26-3. The Seattle Seahawks triumphed over the New England Patriots 23-20, and the Tampa Bay Buccaneers narrowly beat the Detroit Lions 20-16.

The Washington Commanders secured a late 21-18 win against the New York Giants. The Green Bay Packers edged the Indianapolis Colts 16-10 and the Las Vegas Raiders bested the Baltimore Ravens 26-23. The New Orleans Saints showcased their dominance, defeating the Dallas Cowboys 44-19.

The Cleveland Browns outlasted the Jacksonville Jaguars 18-13, while the Arizona Cardinals crushed the Los Angeles Rams 41-10. The Kansas City Chiefs edged the Cincinnati Bengals 26-25 on a last-second field goal. The Pittsburgh Steelers managed a 13-6 victory over the Denver Broncos, and the Houston Texans topped the Chicago Bears 19-13.