The injuries to key running backs Christian McCaffrey of the San Francisco 49ers and J.K. Dobbins of the Los Angeles Chargers have opened up significant opportunities for fantasy football managers.

Isaac Guerendo, a rookie from Louisville, is set to step up as the lead back for the 49ers, while Kimani Vidal faces uncertainty in the Chargers' backfield. Both players present intriguing options for fantasy teams looking to strengthen their rosters as the playoffs approach.