The Week 16 clash features the Denver Broncos facing off against the Los Angeles Chargers, both vying for playoff positioning in the AFC West. The Chargers, despite a strong record against the spread, have struggled recently, particularly in offensive efficiency. They rank low in key metrics since Week 12, which could be problematic against the Broncos' top-rated defense.

Denver's defense has been exceptional, leading the league in EPA allowed and scoring points off turnovers. With a promising young quarterback, the Broncos boast the best record against the spread this season. However, they seek redemption after losing to the Chargers earlier in the season. Expect a fierce contest as both teams aim to solidify their playoff hopes.