The Los Angeles Chargers are set to face the Houston Texans in the NFL Wild Card Round on Saturday, marking the start of the 2025 NFL Playoffs. Under head coach Jim Harbaugh, the Chargers clinched a postseason spot after finishing the regular season with a three-game winning streak, including a decisive victory over the Las Vegas Raiders in Week 18. In contrast, the Texans secured their second consecutive AFC South title, ending their season with a win against the Tennessee Titans.

This matchup features notable absences for the Chargers, as wide receivers Joshua Palmer and Quentin Johnston were sidelined from practice earlier in the week. The game will take place at NRG Stadium in Houston, with kickoff scheduled for 4:30 p.m. ET. The Chargers enter the game as three-point favorites, with the over/under set at 41.5 points. SportsLine's consensus odds reflect a money-line favoring Los Angeles at -157, while Houston is listed as an underdog at +132.