In a tense matchup, the Los Angeles Chargers fell to the Arizona Cardinals 17-15, with the Chargers' defense faltering in the final moments. A crucial unnecessary roughness penalty against rookie cornerback Cam Hart allowed the Cardinals to advance into field goal range, culminating in a game-winning kick from Chad Ryland as time expired.

Despite a strong performance from quarterback Justin Herbert, who threw for 349 yards, the Chargers struggled offensively with key players sidelined. The team faced challenges, including dropped passes and turnovers, leading to their first scoreless first quarter of the season.