Tony Jefferson had a standout preseason performance, particularly against the Dallas Cowboys, where he showcased his skills with 14 tackles, two interceptions, a forced fumble, a sack, and two passes defended. His impressive play earned praise from head coach Jim Harbaugh, who noted his admiration for Jefferson's talent and past successes while playing under his brother in Baltimore. Throughout his career, Jefferson has made a significant impact with 468 total tackles, 9.5 sacks, and four interceptions in 113 games, including experience in the postseason. He is being elevated to the active roster due to starting safety Alohi Gilman's absence in the upcoming game against Carolina.