The Buffalo Bills faced a surprising defeat against the Los Angeles Rams, scoring 42 points but losing by two. This marked a historic moment as they became the first NFL team to score six touchdowns without turnovers and still lose.

Despite a strong offensive performance, head coach Sean McDermott pointed to defensive and special teams errors as critical factors in the loss. The Bills allowed the Rams to convert key third downs and made costly mistakes in special teams, including a blocked punt that led to a touchdown.