No. 1 overall picks in the NFL face scrutiny like no other players, often seen as the harbingers of a franchise's future. Many, like Troy Aikman, thrive, leading their teams to historic victories, while others, such as JaMarcus Russell, become cautionary tales. The journey of a top pick is a blend of personal accolades, team success, and longevity in the league. This piece evaluates the best No. 1 overall picks since 2000, setting a ranking based on individual achievements, team contributions, and the sustainability of their careers.