The upcoming matchup features the Buffalo Bills (10-2) visiting the Los Angeles Rams (6-6) on Sunday. The Bills are favored by 3.5 points and lead the series 9-5, having won the last encounter decisively.

Buffalo's offense ranks highly in scoring and overall performance, while their defense has shown strength against the pass. The Rams, on the other hand, struggle defensively, particularly against the run. Key players include WR Amari Cooper for the Bills and LB Omar Speights for the Rams.

Injuries may impact both teams, with notable players like TE Dalton Kincaid and QB Matthew Stafford dealing with issues. Buffalo has clinched the AFC East title and aims for the conference's top seed, while the Rams are looking to improve their playoff chances.