The Week 13 fantasy football defense rankings are essential for managers facing crucial matchups. Key defenses like the Kansas City Chiefs, Denver Broncos, and Houston Texans are highlighted as top options.

Injury updates are critical, with players such as C.J. Mosley and Nick Bosa listed as questionable, impacting their respective teams' defensive strengths. The Minnesota Vikings and Seattle Seahawks are also discussed as favorable starts based on their recent performances.