San Francisco 49ers running back Christian McCaffrey is set to return to injured reserve due to a PCL injury, with a recovery timeline of approximately six weeks. This effectively ends his fantasy season, although he may return if the team advances deep into the playoffs.

Jordan Mason will also join him on IR with a high ankle sprain, leaving Isaac Guerendo as the likely starting running back. The 49ers may need to acquire additional running backs to bolster their roster.