The New Orleans Saints have achieved a notable track record in drafting impactful players in the first round. Over the years, they have selected a number of players who have made significant contributions to the franchise, with OT Willie Roaf leading the charge as a Hall of Famer and an undeniable force in the offensive line. Following him is Cameron Jordan, a likely future Hall of Famer himself, who has been instrumental in the Saints' defense with an impressive sack total. Deuce McAllister, though not the longest-tenured, is remembered for his exceptional rushing abilities that solidified his place in franchise lore.

Among the other notable first-round picks are Archie Manning, who despite his team's struggles, was able to show flashes of brilliance at quarterback, and George Rogers, the only No. 1 overall pick in franchise history, who had a remarkable rookie season. The list also includes current stars like Marshon Lattimore and Ryan Ramczyk, showcasing the Saints' ability to blend past legends with modern talent. As the 2025 NFL Draft approaches, the history of these first-round picks continues to shape the identity of the franchise.